Gallic Acid Attenuates Dimethylnitrosamine-Induced Liver Fibrosis by Alteration of Smad Phosphoisoform Signaling in Rats
| Autor: | Yuxin Chen, Youwei Wang, Ziping Zhou, Qigui Mo, Gao Zhou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Liver Cirrhosis Male Antioxidant Article Subject medicine.medical_treatment Intraperitoneal injection lcsh:Medicine Mutagen Smad Proteins Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Dimethylnitrosamine Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound In vivo Gallic Acid medicine Animals Protein Isoforms Gallic acid Carcinogen General Immunology and Microbiology lcsh:R Hepatotoxin General Medicine Phosphoproteins Rats 030104 developmental biology chemistry Toxicity human activities Signal Transduction Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2018/1682743 |
| Popis: | Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen, and mutagen. In our previous study, a candidate gallic acid (GA) that widely exists in food and fruit was selected for its capability to alleviate DMN toxicity in vivo. We aimed to investigate the therapeutic potential of GA against DMN-induced liver fibrosis. During the first four weeks, DMN was administered to rats via intraperitoneal injection every other day, except the control group. GA or silymarin was given to rats by gavage once daily from the second to the sixth week. GA significantly reduced liver damage in serum parameters and improved the antioxidant capacity in liver and kidney tissues. Cytokines involved in liver fibrosis were measured at transcriptional and translational levels. These results indicate that GA exhibits robust antioxidant and antifibrosis effects and may be an effective candidate natural medicine for liver fibrosis treatment. |
| Databáze: | OpenAIRE |
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