Lesion location matters: The relationships between white matter hyperintensities on cognition in the healthy elderly
| Autor: | Matthias L. Schroeter, Leonie Lampe, Katrin Arélin, Pierre-Louis Bazin, Arno Villringer, Markus Löffler, A. Veronica Witte, Christopher J. Steele, Jana Kynast, Shahrzad Kharabian-Masouleh |
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| Přispěvatelé: | Brain and Cognition, Brein en Cognitie (Psychologie, FMG) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Aging medicine.medical_specialty Pyramidal Tracts Neuropsychological Tests Audiology behavioral disciplines and activities 050105 experimental psychology Cerebral Ventricles Lesion Executive Function 03 medical and health sciences Cognition 0302 clinical medicine Memory mental disorders medicine Humans Cognitive Dysfunction 0501 psychology and cognitive sciences Cognitive decline Cognitive impairment Brain aging Aged Aged 80 and over business.industry 05 social sciences Original Articles Healthy elderly Middle Aged Magnetic Resonance Imaging White Matter Healthy Volunteers Hyperintensity Frontal Lobe Neurology Cerebral Small Vessel Diseases Female Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow and Metabolism Journal of cerebral blood flow and metabolism, 39(1), 36-43. Nature Publishing Group |
| ISSN: | 0271-678X |
| Popis: | White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort ( n = 702, age range 60 – 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter—including the corticospinal tract—compromised motor speed performance. This study exposes the subtle and subclinical yet detrimental effects of WMH on cognition in healthy elderly, and strongly suggests a causal influence of WMH on cognition by demonstrating the spatial specificity of these effects. |
| Databáze: | OpenAIRE |
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