Activity of Cerebellar Nuclei Neurons Correlates with ZebrinII Identity of Their Purkinje Cell Afferents
| Autor: | Chris I. De Zeeuw, Simona V. Gornati, Martijn Schonewille, Avraham M. Libster, Freek E. Hoebeek, Gerrit Cornelis Beekhof, Cathrin B. Canto |
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| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Neurosciences |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aging
QH301-705.5 Purkinje cell Action Potentials cerebellar nuclei ZebrinII Article 03 medical and health sciences Purkinje Cells 0302 clinical medicine Biological Clocks morphology medicine Animals Neurons Afferent Biology (General) development 030304 developmental biology 0303 health sciences Chemistry General Medicine Climbing fiber Dendrites action potential firing Spontaneous action potential Mice Inbred C57BL Electrophysiology medicine.anatomical_structure nervous system Cerebellar cortex Action potential firing Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cells, 10(10):2686. Multidisciplinary Digital Publishing Institute (MDPI) Cells Volume 10 Issue 10 Cells, Vol 10, Iss 2686, p 2686 (2021) |
| ISSN: | 2073-4409 |
| Popis: | Purkinje cells (PCs) in the cerebellar cortex can be divided into at least two main subpopulations: one subpopulation that prominently expresses ZebrinII (Z+), and shows a relatively low simple spike firing rate, and another that hardly expresses ZebrinII (Z–) and shows higher baseline firing rates. Likewise, the complex spike responses of PCs, which are evoked by climbing fiber inputs and thus reflect the activity of the inferior olive (IO), show the same dichotomy. However, it is not known whether the target neurons of PCs in the cerebellar nuclei (CN) maintain this bimodal distribution. Electrophysiological recordings in awake adult mice show that the rate of action potential firing of CN neurons that receive input from Z+ PCs was consistently lower than that of CN neurons innervated by Z– PCs. Similar in vivo recordings in juvenile and adolescent mice indicated that the firing frequency of CN neurons correlates to the ZebrinII identity of the PC afferents in adult, but not postnatal stages. Finally, the spontaneous action potential firing pattern of adult CN neurons recorded in vitro revealed no significant differences in intrinsic pacemaking activity between ZebrinII identities. Our findings indicate that all three main components of the olivocerebellar loop, i.e., PCs, IO neurons and CN neurons, operate at a higher rate in the Z– modules. |
| Databáze: | OpenAIRE |
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