Distinction Between Papillary Thyroid Hyperplasia and Papillary Thyroid Carcinoma by Immunohistochemical Staining for Cytokeratin 19, Galectin-3, and HBME-1
| Autor: | Mary B. Casey, Ricardo V. Lloyd, Christine M. Lohse |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male endocrine system Pathology medicine.medical_specialty Adolescent endocrine system diseases Galectin 3 Endocrinology Diabetes and Metabolism Pathology and Forensic Medicine Diagnosis Differential Thyroid carcinoma Cytokeratin Endocrinology Biomarkers Tumor medicine Carcinoma Humans Thyroid Neoplasms Aged Aged 80 and over Hyperplasia business.industry Thyroid General Medicine Middle Aged medicine.disease Immunohistochemistry Thyroid Diseases Carcinoma Papillary medicine.anatomical_structure Keratins Anisocytosis Female Histopathology Differential diagnosis business |
| Zdroj: | Endocrine Pathology. 14:55-60 |
| ISSN: | 1046-3976 |
| DOI: | 10.1385/ep:14:1:55 |
| Popis: | The histopathology of papillary thyroid hyperplasia and papillary thyroid carcinoma is similar enough to cause a diagnostic dilemma in a few cases. Both lesions may have papillary fronds with fibrovascular cores, nuclear crowding, and nuclear anisocytosis. Formalin- fixed paraffin-embedded tissues from 30 randomly selected patients with papillary thyroid hyperplasia and an equal number from patients with papillary thyroid carcinoma were analyzed for expression of cytokeratin 19 (CK19), galectin-3, and HBME-1. Cases of papillary thyroid carcinoma had moderate to strong CK19, galectin-3, and HBME-1 reactivity although both CK19 and galectin-3 showed positive staining in a significant number of nonneoplastic thyroid cases. HBME-1 was uncommon in the nonneoplastic cases. These results indicate that HBME-1 may be useful in helping to distinguish papillary thyroid carcinoma from hyperplasia in diagnostically difficult cases. |
| Databáze: | OpenAIRE |
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