Pregnancy level of estradiol attenuated virus-specific humoral immune response in H5N1-infected female mice despite inducing anti-inflammatory protection

Autor: Jill Ascher, Toshiaki Kawano, Martina Kosikova, Hang Xie, Zhiping Ye, Anding Zhang, Courtney Finch, Marcela F. Pasetti
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Epidemiology
medicine.medical_treatment
Anti-Inflammatory Agents
medicine.disease_cause
Pregnancy
humoral immunity
Drug Discovery
Pregnancy Complications
Infectious
Lung
Disease Resistance
Mice
Inbred BALB C
Attenuated vaccine
Estradiol
virus diseases
General Medicine
Th2 response
Infectious Diseases
Ovariectomized rat
Female
medicine.drug_class
030106 microbiology
Immunology
sex-biased
Microbiology
Anti-inflammatory
Article
Steroid
03 medical and health sciences
Immune system
Sex Factors
Orthomyxoviridae Infections
Virology
medicine
Animals
Influenza A Virus
H5N1 Subtype
business.industry
medicine.disease
Influenza A virus subtype H5N1
Immunity
Humoral
Disease Models
Animal
030104 developmental biology
Immunoglobulin G
Humoral immunity
Pregnancy level of estradiol
Parasitology
avian influenza
business
Zdroj: Emerging Microbes & Infections
ISSN: 2222-1751
Popis: Estradiol, a major female steroid produced during pregnancy, has been reported to protect ovariectomized animals against H1N1 influenza infections via its anti-inflammatory effects. However, it remains unclear why pregnant women with high gestational estradiol levels are highly susceptible to influenza infections. This study was aimed to investigate the effects of pregnancy level of estradiol on female immunity against H5N1 infection in Balb/c mice. A sex-dependent susceptibility to H5N1 infection (higher morbidity and higher mortality) was observed in both pregnant and non-pregnant female mice as compared to male mice. Subcutaneous implantation of estradiol pellets increased serum estradiol concentrations of non-pregnant female mice to the pregnancy level. These mice were protected from H5N1 infection through downregulation of pulmonary pro-inflammatory cytokines. However, the production of virus-specific antibodies after infection was significantly delayed in estradiol-implanted mice when compared to placebos. Virus-specific IgG-secreting and IL-4-secreting cells were also reduced in estradiol-implanted mice. Similarly, lower antibody titers to seasonal vaccine antigens were found in pregnant women as compared to non-pregnant females without hormone usage. Our results indicate that estradiol levels equivalent to those found during pregnancy have divergent effects on female immunity against influenza, highlighting the importance of vaccination during pregnancy to prevent severe influenza infections.
Databáze: OpenAIRE
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