trans-Platinum(II) complex of 3-aminoflavone - synthesis, X-ray crystal structure and biological activities in vitro
| Autor: | Justyn Ochocki, Małgorzata Fabijańska, Elzbieta Zyner, Piotr Smolewski, Leszek Szmigiero, Kazimierz Studzian, Arno Pfitzner, Agnieszka J. Rybarczyk-Pirek, Barbara Cebula-Obrzut |
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| Rok vydání: | 2014 |
| Předmět: |
Stereochemistry
ddc:540 Molecular Conformation chemistry.chemical_element Apoptosis Crystal structure DNA Fragmentation Crystallography X-Ray Cell Line Inorganic Chemistry Isomerism Coordination Complexes medicine Cytotoxic T cell Animals Humans Platinum Cisplatin Flavonoids Membrane Potential Mitochondrial Caspase 3 X-ray In vitro chemistry Microscopy Fluorescence 540 Chemie Toxicity medicine.drug Aminoflavone |
| Zdroj: | Dalton transactions (Cambridge, England : 2003). 44(3) |
| ISSN: | 1477-9234 |
| Popis: | This paper describes the synthesis of trans-bis-(3-aminoflavone)dichloridoplatinum(II) (trans-Pt(3-af)2Cl2; TCAP) for use as a potential anticancer compound, and the evaluation of its structure by elemental and spectral analyses, and X-ray crystallography. The complex demonstrated a significant cytotoxic effect against human and murine cancer cell lines, as well as weaker toxicity towards healthy cells (human peripheral blood lymphocytes) in comparison with cisplatin. Various biochemical and morphological methods confirm that the proapoptotic activity of trans-Pt(3-af)2Cl2 is markedly higher than the reference cisplatin. Our results suggest that trans-Pt(3-af)2Cl2 may have a different antitumour specificity from that of cisplatin. |
| Databáze: | OpenAIRE |
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