Comorbidity burden and nonclinical factors associated with sinonasal cancer all‐cause mortality
| Autor: | Jason W. Greenberg, Nosayaba Osazuwa Peters, Greg M. Ward, Matthew C. Simpson, Jastin L. Antisdel, Aleksandr R. Bukatko, Premal B. Desai, Ronald J. Walker, Eric Adjei Boakye |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Cohort Studies 03 medical and health sciences 0302 clinical medicine Cost of Illness Risk Factors Cause of Death Internal medicine medicine Humans 030212 general & internal medicine Survival analysis Retrospective Studies Proportional hazards model business.industry Cancer Sinonasal cancer Middle Aged medicine.disease Comorbidity United States Otorhinolaryngology Quartile 030220 oncology & carcinogenesis Female business Medicaid Paranasal Sinus Neoplasms All cause mortality |
| Zdroj: | The Laryngoscope. 130:1443-1449 |
| ISSN: | 1531-4995 0023-852X |
| Popis: | OBJECTIVE To describe comorbidity burden and nonclinical factors associated with all-cause mortality of sinonasal cancer in the United States. METHODS The National Cancer Database (2004-2013) was queried for adult cases of sinonasal cancer (n = 10,518). Outcome of interest was all-cause mortality. Independent variables included comorbidity score and nonclinical factors such as age, gender, race, facility type, distance to facility, insurance, and income. Survival analysis was conducted via multivariable extended Cox regression with Heaviside adjustments. RESULTS Patients were mostly (79%), male (61%), and mean age of diagnosis was 63.5 years. Approximately one in five patients (18.7%) had a major comorbid condition (Charlson-Deyo score ≥ 1) at diagnosis. After adjusting for clinical factors, increasing comorbidity score was associated with a corresponding increase in hazard of mortality (aHR comorbidity score of 1 = 1.25; 95% CI, 1.16, 1.35), (aHR score of 2+ = 1.61; 95%, CI 1.41, 1.83). Hazard of mortality was also associated with being male (aHR = 1.11; 95% CI, 1.04, 1.17); black (aHR = 1.13, 95% CI, 1.03, 1.24); uninsured (aHR = 1.45; 95% CI, 1.25, 1.68) or on Medicaid (aHR = 1.50; 95% CI, 1.33, 1.69); residence in zip codes with lower median income quartile (aHR |
| Databáze: | OpenAIRE |
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