Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors
| Autor: | Yanming Zhou, Shuncui Liu, Tao Wan, Lupeng Wu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Prognostic variable medicine.medical_specialty China Lymphovascular invasion Perineural invasion lcsh:Surgery 030230 surgery Gastroenterology survival Risk Assessment Disease-Free Survival Resection distal cholangiocarcinoma Cholangiocarcinoma 03 medical and health sciences 0302 clinical medicine Internal medicine Cause of Death Medicine Humans Neoplasm Invasiveness resection Pathological Neoplasm Staging Randomized Controlled Trials as Topic business.industry prognostic factors lcsh:RD1-811 Prognosis Survival Analysis Confidence interval Surgery Biliary Tract Surgical Procedures Bile Duct Neoplasms 030220 oncology & carcinogenesis Meta-analysis Relative risk Female business |
| Zdroj: | Asian Journal of Surgery, Vol 40, Iss 2, Pp 129-138 (2017) Scipedia Open Access Scipedia SL |
| ISSN: | 0219-3108 |
| Popis: | Summary Background/Objective This study aimed to assess the available evidence on the survival of distal cholangiocarcinoma (DCC) patients following resection with curative intent and analyze the prognostic factors. Methods Relevant studies published between January 2000 and January 2015 were identified by searching PubMed and Embase and reviewed systematically. Summary relative risks (RR) and 95% confidence intervals (95% CI) were estimated using random-effects models. Results A total of 39 observational studies involving 3258 patients were included in the review. R0 resection was achieved in 84% (range, 46–100%) of patients. The median 5-year overall survival rate after resection was 37% (range, 13–54%), with corresponding rate of 44% (range, 27–63%) in R0 resection. The meta-analysis for 25 studies showed that R1 resection (RR 2.36, 95% CI 1.89–2.93), lymph node metastasis (RR 2.35, 95% CI 1.89–2.93), perineural invasion (RR 1.96, 95% CI 1.64–2.34), lymphatic invasion (RR 1.84, 95% CI 1.47–2.31), vascular invasion (RR 1.99, 95% CI 1.40–2.82), pancreatic invasion (RR 2.13, 95% CI 1.39–3.27), and pathological tumor stage ≥ T3 (RR 1.56, 95% CI 1.25–1.93) were associated with shorter survival. Conclusion In general, prognosis of DCC after resection is poor. R0 resection results in a substantially improved survival and represents one of the most important prognostic variables. |
| Databáze: | OpenAIRE |
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