Acarbose treatment enhances mid-regional pro-atrial natriuretic peptide concentrations in non-diabetic individuals: further evidence for a common cardiometabolic pathway?
| Autor: | Ayman M. Arafat, Andrea Sparwasser, Andreas L. Birkenfeld, Martin O. Weickert, Wolfgang Bernigau, Olga Pivovarova, Natalia Rudovich, Andreas Pfeiffer, Andreas Bergmann, A. Traberth |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes Carbohydrate metabolism Double-Blind Method Internal medicine Internal Medicine medicine Natriuretic peptide Humans Hypoglycemic Agents Protein Precursors Acarbose Glycated Hemoglobin Cross-Over Studies business.industry Insulin Middle Aged medicine.disease Postprandial Period Obesity Postprandial Endocrinology Diabetes Mellitus Type 2 Blood sugar regulation Female business Atrial Natriuretic Factor medicine.drug |
| Zdroj: | Diabetologia. 55(12) |
| ISSN: | 1432-0428 |
| Popis: | To the Editor: Heinisch et al reported that acute infusion of B-type natriuretic peptide (NP) enhances the initial glucose distribution, resulting in a decrease of postload glucose concentrations by beta cell-independent mechanisms in healthy individuals [1]. This study added to growing evidence regarding a close pathophysiological link between NPs and metabolic traits in obesity, type 2 diabetes and associated diseases [2]. The mechanisms by which NP regulates glucose metabolism are not fully understood, but a reciprocal relationship between glucose regulation and NP has been suggested in type 2 diabetes and cardiovascular diseases (CVDs) [1, 2]. In addition, we and others observed the same type of relations between insulin and NP in obesity [3, 4]. Previous large-cohort observations such as the Study to Prevent NIDDM (STOP-NIDDM) [5, 6] indicate that reduction of postprandial glucose load may be involved in the prevention of both type 2 diabetes and incident hypertension, pointing to a potential ‘bi-directional relationship’ |
| Databáze: | OpenAIRE |
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