A placebo-controlled blind trial of cyclosporin-A in prevention of corneal graft rejection in rabbits
Autor: | T A Bell, K G McCullagh, D L Easty |
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Rok vydání: | 1982 |
Předmět: |
Graft Rejection
medicine.medical_specialty Necrosis Endothelium medicine.medical_treatment Drug Evaluation Preclinical Urology Cyclosporins Placebo Cornea Corneal Transplantation Cellular and Molecular Neuroscience Cyclosporin a medicine Animals Corneal transplantation business.industry Sensory Systems Epithelium Surgery Ophthalmology medicine.anatomical_structure Rabbits medicine.symptom business Research Article |
Zdroj: | British Journal of Ophthalmology. 66:303-308 |
ISSN: | 0007-1161 |
DOI: | 10.1136/bjo.66.5.303 |
Popis: | Cyclosporin-A (CyA) administered to rabbits intramuscularly in a dose of 25 mg/kg/day for 14 days following interlamellar corneal grafting had a significant effect in preventing rejection of the corneal graft (p less than 0.05), and the benefit was maintained. Rejection was attended by an initial mild inflammatory reaction and followed by a protracted intense response involving a variety of cell types, with subsequent loss of epithelium. endothelium and keratocytes, and the development of areas of stromal necrosis. CyA suppressed this rejection response. |
Databáze: | OpenAIRE |
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