Gabapentin as add-on therapy in children with refractory partial seizures: a 24-week, multicentre, open-label study

Autor: Richard Appleton, Stephen Maton, Jeannine Alexander, E. A. Garofalo, Klaus Fichtner, L. LaMoreaux, Guta Murray
Rok vydání: 2007
Předmět:
Zdroj: Developmental Medicine & Child Neurology. 43:269-273
ISSN: 1469-8749
0012-1622
Popis: The efficacy and safety of gabapentin as add-on therapy for refractory partial seizures in 237 children, aged 3 to 12 years were evaluated over a 6-month period. All children received gabapentin at 24 to 70 mg/kg/day. Efficacy variables included the percent change in seizure frequency and the responder rate (defined as those patients who showed >50% reduction in seizure frequency). For all partial seizures, the median percent change in seizure frequency was -34% and the overall responder rate was 34%. Simple partial seizures showed a median reduction of -53%; complex partial seizures, -38%; and secondarily generalized tonic-clonic seizures, -35%. Thirteen patients (5%) withdrew during the 6-month period because of adverse events. Concurrent antiepileptic medication remained unchanged in 185 patients (78%), was decreased in 27 (11%), and increased in 25 (11%) patients. This 6-month follow-up study has demonstrated that gabapentin was well tolerated and appeared to show a sustained efficacy in a large population of children with refractory partial and secondarily generalized tonic-clonic seizures.
Databáze: OpenAIRE
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