Association of (GT)n Repeats Promoter Polymorphism of Heme Oxygenase-1 Gene with Serum Bilirubin Levels in Healthy Indian Adults
| Autor: | Selma D'Silva, Kanjaksha Ghosh, Malay B. Mukherjee, Vikrant Borse, Roshan B. Colah |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Bilirubin India Biology Polymerase Chain Reaction Young Adult chemistry.chemical_compound Gene Frequency Polymorphism (computer science) Humans Allele Dinucleotide Repeats Promoter Regions Genetic Heme Allele frequency Gene Alleles Genetics (clinical) Hyperbilirubinemia Polymorphism Genetic Electrophoresis Capillary Promoter General Medicine Middle Aged Molecular biology Heme oxygenase chemistry Heme Oxygenase-1 |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 15:215-218 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2010.0132 |
| Popis: | Aim: The present study was undertaken to investigate a length polymorphism of (GT)n repeats of the heme oxygenase-1 (HMOX-1) gene and its association with serum bilirubin levels in apparently healthy adults. Methods: A total of 211 individuals (normal hematology and liver function test) with bilirubin levels of 1.7 to 22.2 μM were studied. The (GT)n repeats were analyzed by PCR and subsequent sizing by capillary electrophoresis on the ABI Prism 310 Genetic Analyzer. Results: Polymorphisms of the (GT)n repeats were grouped into three classes: short (S) alleles ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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