Bromocriptine suppression of dispersed pituitary lactotrophs from estrogen-pretreated rats: a quantitative electron microscopic study
| Autor: | K. Kovacs, John V. Milligan, R. Croxford, D. J. McComb |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.drug_class Cytoplasmic Granules Cell morphology Prolactin cell Physiology (medical) Internal medicine medicine Animals Incubation Bromocriptine Cell Nucleus Pharmacology Hyperplasia Chemistry Granule (cell biology) Estrogens General Medicine Prolactin Rats Pituitary Hormones Endocrinology Estrogen Pituitary Gland Ultrastructure medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 60:154-159 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y82-025 |
| Popis: | Dispersed rat lactotrophs were treated with bromocriptine (10−10 M) for either 30 min or 3 h to investigate its effect on cell morphology using light and electron microscopy and ultrastructural morphometry. After 30 min, lactotrophs treated with bromocriptine exhibited an increase in storage granule size (p < 0.05). Crinophagy was also evident and a significant increase in lysosome volume density was observed (p < 0.001). However, no significant change in prolactin content in the media was detected until 3 h of incubation in bromocriptine (p < 0.05). At this time a nonsignificant decrease in Golgi region volume density was also observed. |
| Databáze: | OpenAIRE |
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