Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial

Autor: Otlu Onder, Karabulut Aysun Bay, Eltas Seydanur Dengizek, Cicek Arife, Eltas Abubekir, Dundar Serkan
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Saliva
Time Factors
Gastroenterology
Antioxidants
law.invention
Root Planing
030207 dermatology & venereal diseases
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Transforming Growth Factor beta
Malondialdehyde
Dental Plaque Index
Middle Aged
Oxidants
Glutathione
Treatment Outcome
8-Hydroxy-2'-Deoxyguanosine
Population study
Original Article
Female
Periodontal Index
Adult
TGF-β
medicine.medical_specialty
Periodontal examination
Enzyme-Linked Immunosorbent Assay
Placebo
Nitric Oxide
Statistics
Nonparametric
03 medical and health sciences
Oxidants
Photochemical
Ozone
Internal medicine
medicine
Periodontal Pocket
Humans
General Dentistry
Peroxidase
Inflammation
business.industry
Deoxyguanosine
Reproducibility of Results
030206 dentistry
Periodontal treatment
medicine.disease
Chronic periodontitis
lcsh:RK1-715
chemistry
lcsh:Dentistry
Chronic Periodontitis
Dental Scaling
business
Zdroj: Journal of Applied Oral Science v.27 2019
Journal of applied oral science
Universidade de São Paulo (USP)
instacron:USP
Journal of Applied Oral Science, Vol 27, Iss 0 (2019)
Journal of Applied Oral Science
Popis: Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
Databáze: OpenAIRE
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