Stabilization of beta-catenin impacts pancreas growth
| Autor: | Janet Lau, Matthias Hebrok, Makoto Mark Taketo, Pedro Luis Herrera, Patrick W. Heiser |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Time Factors Organogenesis Fibroblast Growth Factor 10/physiology Biology Fibroblast growth factor Epithelial Cells/cytology/physiology Mice Internal medicine Beta Catenin/ physiology medicine Animals Hedgehog Proteins Progenitor cell Pancreas Molecular Biology Hedgehog beta Catenin Cell Proliferation Homeodomain Proteins ddc:616 FGF10 Stem Cells/metabolism Stem Cells Pancreas/cytology/ embryology/ growth & development Wnt signaling pathway Epithelial Cells Organ Size Homeodomain Proteins/physiology Cell biology medicine.anatomical_structure Endocrinology Catenin Trans-Activators Trans-Activators/metabolism/physiology PDX1 Fibroblast Growth Factor 10 Developmental Biology Signal Transduction |
| Zdroj: | Development, Vol. 133, No 10 (2006) pp. 2023-2032 |
| ISSN: | 0950-1991 |
| Popis: | A recent study has shown that deletion of β-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of β-catenin within mouse pancreatic epithelium can have divergent effects on both organ formation and growth. Robust stabilization of β-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells. Together, these perturbations in early pancreatic specification culminate in a severe reduction of pancreas mass and postnatal lethality. By contrast, inducing the stabilized form of β-catenin at a later time point in pancreas development causes enhanced proliferation that results in a dramatic increase in pancreas organ size. Taken together, these data suggest a previously unappreciated temporal/spatial role forβ-catenin signaling in the regulation of pancreas organ growth. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|