Preparation of N-Substituted N-Arylsulfonylglycines and Their Use in Peptoid Synthesis

Autor:	Eric Biron, Antoine Derson, Steve Jobin, Claire Herby, Simon Vézina-Dawod
Rok vydání:	2015
Předmět:	Molecular Structure Organic Chemistry Glycine Peptoid Biochemistry Combinatorial chemistry Peptoids chemistry.chemical_compound Monomer chemistry Chemical diversity Side chain Organic chemistry Amines Physical and Theoretical Chemistry Peptides Solid-Phase Synthesis Techniques
Zdroj:	Organic Letters. 17:5626-5629
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.5b02862
Popis:	To increase the chemical diversity accessible with peptoids and peptide-peptoid hybrids, N-alkylated arylsulfonamides were used to prepare side chain protected N-substituted glycines compatible with solid-phase synthesis. The described procedures give access to peptoid monomers bearing a wide variety of functional groups from commercially available amines in four straightforward steps. The prepared N-substituted N-arylsulfonylglycines were used as monomers in solid-phase synthesis to introduce relevant functionalized side chains into peptoid oligomers and peptide-peptoid hybrids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eebd28eae5fba68536b7bba09aae3d https://doi.org/10.1021/acs.orglett.5b02862 Zobrazit plný text záznamu