Greater coronary lipid core plaque assessed by near-infrared spectroscopy intravascular ultrasound in patients with elevated xanthine oxidoreductase: a mechanistic insight

Autor: Naoto Mori, Hideki Kitahara, Seigo Akari, Yoshihide Fujimoto, Yoshio Kobayashi, Takashi Nakamura, Kazuya Tateishi, Takaaki Matsuoka, Yuichi Saito, Tadayuki Kadohira, Takayo Murase, Kan Saito
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Xanthine Dehydrogenase
medicine.medical_treatment
Inflammation
Coronary Artery Disease
030204 cardiovascular system & hematology
Coronary Angiography
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
Percutaneous Coronary Intervention
0302 clinical medicine
Internal medicine
Diabetes mellitus
Intravascular ultrasound
medicine
Humans
Prospective Studies
030212 general & internal medicine
Reactive hyperemia
Ultrasonography
Interventional
Coronary atherosclerosis
Aged
Spectroscopy
Near-Infrared
medicine.diagnostic_test
business.industry
Percutaneous coronary intervention
medicine.disease
Plaque
Atherosclerotic
chemistry
Cardiology
Uric acid
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Biomarkers
Follow-Up Studies
Zdroj: Heart and Vessels. 36:597-604
ISSN: 1615-2573
0910-8327
DOI: 10.1007/s00380-020-01730-w
Popis: Elevated serum uric acid level was reportedly associated with greater coronary lipid plaque. Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine metabolism and believed to play an important role in coronary atherosclerosis. However, the relation of XOR to coronary lipid plaque and its mechanism are unclear. Patients with stable coronary artery disease undergoing elective percutaneous coronary intervention under near-infrared spectroscopy intravascular ultrasound (NIRS-IVUS) guidance were prospectively enrolled. They were divided into three groups according to serum XOR activities: low, normal, and high. Coronary lipid core plaques in non-target vessels were evaluated by NIRS-IVUS with lipid core burden index (LCBI) and a maximum LCBI in 4 mm (maxLCBI4mm). Systemic endothelial function and inflammation were assessed with reactive hyperemia index (RHI) and high-sensitivity C-reactive protein, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Of 68 patients, 26, 31, and 11 were classified as low, normal, and high XOR activity groups. LCBI (474.4 ± 171.6 vs. 347.4 ± 181.6 vs. 294.0 ± 155.9, p = 0.04) and maxLCBI4mm (102.1 ± 56.5 vs. 65.6 ± 48.5 vs. 55.6 ± 37.8, p = 0.04) were significantly higher in high XOR group than in normal and low XOR groups. Although RHI was significantly correlated with body mass index, diabetes, current smoking, and high-density lipoprotein cholesterol, no relation was found between XOR activity and RHI. There were also no relations between XOR activity and C-reactive protein, neutrophil-to-lymphocyte ratio, or platelet-to-lymphocyte ratio. In conclusion, elevated XOR activity was associated with greater coronary lipid core plaque in patients with stable coronary artery disease, without significant relations to systemic endothelial function and inflammation.
Databáze: OpenAIRE
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