RIT2 Polymorphisms: Is There a Differential Association?
| Autor: | Behnam Safarpour Lima, Shaghayegh Taghavi, Monavvar Andarva, Mahmoud Shekari Khaniani, Parasto Shokraeian, Tannaz Safaralizadeh, Peyman Petramfar, Ali Kowsari, Minoo Atakhorrami, Abolfazl Movafagh, Gholam Ali Shahidi, Azadeh Ahmadifard, Tahereh Dadkhah, Mina Ohadi, Marzieh Motallebi, Babak Emamalizadeh, Hossein Darvish, Elham Alehabib, Neda Shahmohammadibeni, Ali Khaligh, Javad Jamshidi, Mohammad Javad Soltani Banavandi, Somayyeh Kazeminasab, Mehdi Khorrami, Ehteram Khademi, Akbar Biglarian, Abbas Tafakhori, Arash Mirabzadeh, Amir Ehtesham Shafiei Zarneh, Atena Fazeli |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Bipolar Disorder Parkinson's disease Neurology Genotype Essential Tremor Neuroscience (miscellaneous) Genome-wide association study Single-nucleotide polymorphism Disease Bioinformatics Polymerase Chain Reaction Polymorphism Single Nucleotide 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Asian People Risk Factors mental disorders medicine Humans Genetic Predisposition to Disease Bipolar disorder Autistic Disorder Aged Monomeric GTP-Binding Proteins Genetics Essential tremor Parkinson Disease Middle Aged medicine.disease 030104 developmental biology Autism Female Psychology 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Molecular Neurobiology. 54:2234-2240 |
| ISSN: | 1559-1182 0893-7648 |
| DOI: | 10.1007/s12035-016-9815-4 |
| Popis: | Neurological disorders include a wide variety of mostly multifactorial diseases related to the development, survival, and function of the neuron cells. Single-nucleotide polymorphisms (SNPs) have been extensively studied in neurological disorders, and in a number of instances have been reproducibly linked to disease as risk factors. The RIT2 gene has been recently shown to be associated with a number of neurological disorders, such as Parkinson's disease (PD) and autism. In the study reported here, we investigated the association of the rs12456492 and rs16976358 SNPs of the RIT2 gene with PD, essential tremor (ET), autism, schizophrenia (SCZ), and bipolar disorder (BPD; total of 2290 patients), and 1000 controls, by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Significant association was observed between rs12456492 and two disorders, PD and ET, whereas rs16976358 was found to be associated with autism, SCZ, and BPD. Our findings are indicative of differential association between the RIT2 SNPs and different neurological disorders. |
| Databáze: | OpenAIRE |
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