Decreased expression of KLF6 and its significance in gastric carcinoma
| Autor: | Nan-zhi Liu, Wei-Zheng Wang, Jun-chuan Li, Chang-Hua He, Qiu Zhao, Yue-sha Yuan, Xiao-Ping Tan, Cheng-ming Hu, Qing Zhang |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Cyclin-Dependent Kinase Inhibitor p21 Male Cancer Research Pathology medicine.medical_specialty Kruppel-Like Transcription Factors medicine.disease_cause Immunoenzyme Techniques Stomach Neoplasms Proliferating Cell Nuclear Antigen Proto-Oncogene Proteins Kruppel-Like Factor 6 Humans Medicine Clinical significance Survival rate Aged Neoplasm Staging Aged 80 and over Regulation of gene expression biology business.industry digestive oral and skin physiology Hematology General Medicine Middle Aged Prognosis digestive system diseases Proliferating cell nuclear antigen Gene Expression Regulation Neoplastic Survival Rate KLF6 Oncology Gastric Mucosa Tumor progression Lymphatic Metastasis biology.protein Immunohistochemistry Female business Carcinogenesis Follow-Up Studies |
| Zdroj: | Medical Oncology. 27:1295-1302 |
| ISSN: | 1559-131X 1357-0560 |
| Popis: | To study the expression of the Kruppel-like transcription factor 6 (KLF6) in human gastric carcinoma and normal gastric mucosa tissues, and to explore the role of KLF6 in the carcinogenesis and tumor progression and its clinical significance. Expression of KLF6, P21WAF1 and PCNA was investigated by immunohistochemistry for 69 surgically resected gastric carcinoma tissues and corresponding normal gastric mucosa tissues, respectively. The correlations of KLF6 expression with clinicopathological characteristics, P21WAF1 and PCNA were examined. Positive-expression of KLF6 was 64 out of 69 cases (92.8%) in normal gastric mucosa and only 23 cases (33.3%) in gastric carcinoma. Expression of KLF6 in the gastric carcinoma was remarkably lower than normal gastric mucosa. Decreased expression of KLF6 in gastric carcinoma was significantly associated with histological differentiation (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink