Association of human herpesvirus 6 reactivation with severe cytomegalovirus-associated disease in orthotopic liver transplant recipients
| Autor: | Stacey Supran, Laurie Gibbons, Eunhui Cho, Jeffrey A. DesJardin, Barbara G. Werner, David R. Snydman |
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| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Human cytomegalovirus Adult Male medicine.medical_specialty medicine.medical_treatment Herpesvirus 6 Human Congenital cytomegalovirus infection Cytomegalovirus Liver transplantation Antibodies Viral Organ transplantation Betaherpesvirinae Medicine Humans Risk factor Retrospective Studies biology business.industry virus diseases Herpesviridae Infections Middle Aged medicine.disease biology.organism_classification Liver Transplantation Transplantation Infectious Diseases Immunology Cytomegalovirus Infections Human herpesvirus 6 Female Virus Activation business |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 33(8) |
| ISSN: | 1058-4838 |
| Popis: | To explore the possible interaction between human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) in patients who have undergone organ transplantation, stored serum samples from 139 orthotopic liver transplant recipients were tested for HHV-6 immunoglobulin (Ig) G and IgM antibodies. HHV-6 reactivation occurred in 87 patients (62.6%) and was associated with CMV disease (P = .01), severe CMV-associated disease (P = .01), older age (P = .005), and use of muromonab-CD3 (Orthoclone; Orthobiotech) as treatment for rejection (P = .02). Trends for an association between HHV-6 reactivation and invasive fungal disease (P = .12), bacteremia (P = .10), and graft loss (P = .12) were seen. In a multivariate analysis of risk factors for severe CMV-associated disease, HHV-6 reactivation (relative risk [RR], 3.5; 95% confidence interval [CI], 1.2-10.2; P = .02), CMV donor-positive-recipient-negative match (RR, 5.7; 95% CI, 2.5-13.2; P |
| Databáze: | OpenAIRE |
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