Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer’s Disease Patients
| Autor: | Kianna Musaraca, Matthew K. Tobin, William G. Honer, Ahmed Disouky, David A. Bennett, Aashutosh Shetti, Orly Lazarov, Abdullah Bheri, Konstantinos Arfanakis, Robert J. Dawe, Namhee Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Doublecortin Domain Proteins
Male Aging Doublecortin Protein Neurogenesis Hippocampus Hippocampal formation Biology Cohort Studies Nestin 03 medical and health sciences Cognition 0302 clinical medicine Neural Stem Cells SOX2 Neuroblast Alzheimer Disease Proliferating Cell Nuclear Antigen Genetics medicine Humans Cells Cultured 030304 developmental biology Aged 80 and over Neurons 0303 health sciences SOXB1 Transcription Factors Neuropeptides Cell Biology Human brain Neural stem cell medicine.anatomical_structure nervous system Molecular Medicine Female SNARE Proteins Microtubule-Associated Proteins Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell Stem Cell. 24:974-982.e3 |
| ISSN: | 1934-5909 |
| DOI: | 10.1016/j.stem.2019.05.003 |
| Popis: | Whether hippocampal neurogenesis persists throughout life in the human brain is not fully resolved. Here, we demonstrate that hippocampal neurogenesis is persistent through the tenth decade of life and is detectable in patients with mild cognitive impairments and Alzheimer's disease. In a cohort of 18 participants with a mean age of 90.6 years, Nestin+Sox2+ neural progenitor cells (NPCs) and DCX+ neuroblasts and immature neurons were detected, but their numbers greatly varied between participants. Nestin+ cells localize in the anterior hippocampus, and NPCs, neuroblasts, and immature neurons are evenly distributed along the anterior to posterior axis. The number of DCX+PCNA+ cells is reduced in mild cognitive impairments, and higher numbers of neuroblasts are associated with better cognitive status. The number of DCX+PCNA+ cells correlates with functional interactions between presynaptic SNARE proteins. Our results suggest that hippocampal neurogenesis persists in the aged and diseased human brain and that it is possibly associated with cognition. |
| Databáze: | OpenAIRE |
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