Tissue Doppler and Speckle Tracking Echocardiography Assessment of Left Ventricular Function in Children with Cystic Fibrosis
| Autor: | Nurettin Ünal, Sakine Işık, Nuh Yilmaz, Ozgur Kizilca, Nevin Uzuner, Mustafa Kir, Tülay Demircan |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adolescent Cystic Fibrosis Diastole Speckle tracking echocardiography 030204 cardiovascular system & hematology Cystic fibrosis Ventricular Function Left 03 medical and health sciences Ventricular Dysfunction Left 0302 clinical medicine Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Interventricular septum Prospective Studies Stage (cooking) Prospective cohort study Child Subclinical infection Ejection fraction business.industry medicine.disease medicine.anatomical_structure 030228 respiratory system Echocardiography Child Preschool Cardiology Cardiology and Cardiovascular Medicine business |
| Popis: | Background Cystic fibrosis may lead to left ventricular (LV) dysfunction. This dysfunction can be documented by methods such as tissue Doppler echocardiographic (TDI) imaging and two-dimensional speckle tracking echocardiography (STE) in early stage. Study design This was prospective cohort study. Methods A total of 34 patients diagnosed with cystic fibrosis (mean age and SD 9.9 +/- 4.9 years) and 37 healthy control subjects with a comparable gender and age distribution (mean age 9.8 +/- 4.3) were studied. The results for the two groups were compared along with the results of published reports. Results No significant relationship was found between the groups in terms of systolic and diastolic measurements of the interventricular septum and posterior left ventricular wall, and ejection fraction (P > .05). Myocardial performance indexes of left ventricular free wall and interventricular septum increased in the patient group compared with the controls (P < .05). As measured by STE, seven segments in the LV myocardial longitudinal strain and three segments in the LV myocardial circumferential strain showed significant reductions in patients with cystic fibrosis compared with controls (P < .05). The longitudinal global, circumferential global, and total global strain values had no significant difference between the groups (P > .05). Longitudinal strain rates and circumferential strain rates were both lower in five segments in the patient group (P < .05). Conclusions Tissue Doppler echocardiographic imaging and STE may help identifying subclinical LV dysfunction in cystic fibrosis patients with unremarkable conventional echocardiography. They may be considered for the routine follow-up of cystic fibrosis patients. |
| Databáze: | OpenAIRE |
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