Heat shock activation of NFkB in rat liver is mediated by interleukin-1
| Autor: | Lorenza Tacchini, Elena Anzon, L Radice, Aldo Bernelli-Zazzera, Giovanna Pogliaghi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Hepatoblastoma
Male Transcriptional Activation Hot Temperature medicine.drug_class medicine.medical_treatment Biophysics Biochemistry NFkB Structural Biology Heat shock protein Genetics medicine Tumor Cells Cultured Animals Rats Wistar Molecular Biology Transcription factor Messenger RNA Chemistry NF-kappa B Interleukin Cell Biology Receptor antagonist Molecular biology Rats Heat shock factor Cytokine Heat shock Liver Shock (circulatory) medicine.symptom Interleukin-1 |
| Zdroj: | FEBS letters. 372(2-3) |
| ISSN: | 0014-5793 |
| Popis: | Exposure to high temperature (heat shock) activates the transcription factor NFkB in the liver of the living rat, but is not effective in hepatoblastoma cells in culture: on the contrary, activation of the heat shock transcription factor (HSF) occurs under both conditions. Pre-treatment of the rat with IL-1 receptor antagonist suppresses the activation of NFkB, which seems to be mediated by the release of this cytokine, but does not hamper the activation of HSF and the concurrent induction of hsp 70 mRNA. IL-1 activity actually shows a strong, albeit transient, increase in the blood of heat shocked rats. |
| Databáze: | OpenAIRE |
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