The neurodevelopmental morbidity of children born after assisted reproductive technology: a Nordic register study from the Committee of Nordic Assisted Reproductive Technology and Safety group
| Autor: | Kristiina Rönö, Essi Rissanen, Christina Bergh, Ulla-Britt Wennerholm, Signe Opdahl, Liv Bente Romundstad, Anna-Karina Aaris Henningsen, Anne Lærke Spangmose, Anja Pinborg, Mika Gissler, Aila Tiitinen |
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| Přispěvatelé: | Department of Obstetrics and Gynecology, Clinicum, HUS Gynecology and Obstetrics, University of Helsinki |
| Rok vydání: | 2021 |
| Předmět: |
RISK
Reproductive Techniques Assisted DEFICIT HYPERACTIVITY DISORDER Autism Spectrum Disorder Assisted reproduction Obstetrics and Gynecology UNITED-STATES attention-deficit and hyperactivity disorder ASSOCIATION learning and motor functioning disorder Embryo Transfer INFERTILITY PREVALENCE Reproductive Medicine 3123 Gynaecology and paediatrics Pregnancy ADOLESCENCE Tic Disorders SURVEILLANCE Humans Female HEALTH Morbidity Child tic disorder |
| Zdroj: | Fertility and sterility. 117(5) |
| ISSN: | 1556-5653 |
| Popis: | Objective: To assess the risk of neurodevelopmental disorders in singletons born after the use of assisted reproductive technology (ART) compared with singletons born without the use of ART. Design: Nordic register-based study. Setting: Cross-linked data from Medical Birth Registers and National ART and Patient Registers; liveborn singletons in 1995-2014 in Denmark and Finland, 2005-2015 in Norway, and 1995-2015 in Sweden with follow-up to 2014 (Denmark and Finland) or 2015 (Norway and Sweden). Patients: A total of 5,076,444 singletons: 116,909 (2.3%) born with and 4,959,535 (97.7%) born without the use of ART (non-ART). Interventions: In vitro fertilization, intracytoplasmic sperm injection, and fresh and frozen embryo transfer. Main Outcome Measures: The primary outcomes (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, codes) were learning and motor functioning disorders (F80-F83), autism spectrum disorder (F84), attention-deficit/hyperactivity disorder and conduct disorders (F90-F92), and tic disorders (F95). Crude hazard ratios (HRs) and adjusted hazard ratios (aHRs) with 95% confidence intervals were calculated. Results: Singletons in the ART cohort had a higher adjusted risk of learning and motor functioning disorders (HR, 1.01 [0.96-1.07]; aHR, 1.17 [1.11-1.24]) and a tendency toward a higher risk of autism spectrum disorder (HR, 1.12 [1.04-1.21]; aHR, 1.07 [0.98-1.16]) and attention-deficit/hyperactivity disorder and conduct disorders (HR, 0.82 [0.77-0.86]; aHR, 1.17 [0.99-1.12]) but not of tic disorders (HR, 1.21 [1.06-1.38]; aHR, 1.17 [0.96-1.27]). No differences in risk were found between children born after in vitro fertilization and intracytoplasmic sperm injection or after fresh and frozen embryo transfer. Conclusions: Our findings of only small differences in neurodevelopment between ART and non-ART singletons are reassuring and in line with previous studies. (C) 2022 by American Society for Reproductive Medicine. |
| Databáze: | OpenAIRE |
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