Recent advances in the histological and molecular classification of endometrial stromal neoplasms
| Autor: | Jochen K. Lennerz, Joana Ferreira, Esther Oliva, Ana Félix |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Stromal cell Uterus Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Molecular classification Endometrial Stromal Tumors Medicine Humans Molecular Biology Endometrial stromal sarcoma business.industry Cell Biology General Medicine medicine.disease Endometrial Neoplasms 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Endometrial stromal nodule Immunohistochemistry Female Sarcoma business Endometrial stromal tumor |
| Zdroj: | Virchows Archiv : an international journal of pathology. 473(6) |
| ISSN: | 1432-2307 |
| Popis: | This review addresses known features and recent developments in the histological, immunohistochemical, and molecular characterization of endometrial stromal neoplasms. We discuss the spectrum of these tumors, from the benign endometrial stromal nodule to low-grade endometrial stromal sarcoma to uterine undifferentiated sarcomas with a special emphasis on the expanding group of high-grade stromal sarcomas, recently added to the 2014 WHO classification, not only discussing the well-established YWHAE-FAM22 tumors but also two new groups, presenting with BCOR alterations including those with BCOR tandem internal duplications or NTRK fusions. It is likely that this high-grade category of endometrial stromal tumors will expand as increasing molecular data is available. |
| Databáze: | OpenAIRE |
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