The net clinical benefit of personalized antiplatelet therapy in patients undergoing percutaneous coronary intervention
| Autor: | Andrea Podczeck-Schweighofer, Georg Delle-Karth, Jolanta M. Siller-Matula, Marcel Francesconi, Günter Christ, Carina Gruber, Bernd Jilma, Cornelia Dechant, Katharina Grohs |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Prasugrel Ticlopidine Platelet Aggregation medicine.medical_treatment Coronary Artery Disease Thiophenes Piperazines Coronary artery disease Percutaneous Coronary Intervention Internal medicine medicine Humans Prospective Studies Precision Medicine Prospective cohort study Aged business.industry Hazard ratio Percutaneous coronary intervention General Medicine Middle Aged Clopidogrel medicine.disease Surgery Relative risk Multivariate Analysis Cardiology Purinergic P2Y Receptor Antagonists Regression Analysis Female business Prasugrel Hydrochloride Mace Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Clinical science (London, England : 1979). 128(2) |
| ISSN: | 1470-8736 |
| Popis: | This was a prospective study comparing two groups: personalized and non-personalized treatment with P2Y12 receptor blockers during a 12-month follow-up. We aimed to investigate whether personalized antiplatelet treatment in patients with high on-treatment platelet reactivity (HTPR) improves clinical outcome. Platelet reactivity was assessed by adenosine diphosphate induced aggregation using a multiple electrode aggregometry (MEA) in 798 patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). Patients with HTPR received up to four repeated loading doses of clopidogrel or prasugrel in the personalized treatment group (n=403), whereas no change in the treatment strategy was undertaken in patients with HTPR in the non-personalized treatment group (n=395). There were fewer major adverse cardiac events (MACE) in the personalized treatment group than in the non-personalized treatment group (7.4% compared with 15.3% respectively; P |
| Databáze: | OpenAIRE |
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