Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure
| Autor: | Mario Catena-Dell'Osso, Donatella Marazziti, Diana Ceresoli, Eugenio Picano, L. Dell'Osso, Elisa Schiavi, Ciro Conversano, Stefano Baroni |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Biochemistry Ionizing radiation Radiation Ionizing Drug Discovery medicine Animals Humans Psychiatry Pharmacology Radiotherapy business.industry Mental Disorders Organic Chemistry Neurogenesis Myelin sheaths Cancer Brain Cognition Dose-Response Relationship Radiation Environmental Exposure medicine.disease Pathophysiology Radiation exposure Increased risk Molecular Medicine business Cognition Disorders |
| Popis: | Radiation exposure leads to an increased risk for cancer and, possibly, additional ill-defined non-cancer risk, including atherosclerotic, cardiovascular, cerebro-vascular and neurodegenerative effects. Studies of brain irradiation in animals and humans provide evidence of apoptosis, neuro-inflammation, loss of oligo-dendrocytes precursors and myelin sheaths, and irreversible damage to the neural stem compartment with long-term impairment of adult neurogenesis. With the present paper we aim to present a comprehensive review on brain effects of radiation exposure, with a special focus on its impact on cognitive processes and psychological functions, as well as on their possible role in the pathophysiology of different psychiatric disorders. |
| Databáze: | OpenAIRE |
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