TSC-22 up-regulates collagen 3a1 gene expression in the rat heart
| Autor: | Jani Aro, Heikki Ruskoaho, Juha Näpänkangas, Annina Kelloniemi, Jaana Rysä, Erja Mustonen, Elina Koivisto |
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| Přispěvatelé: | Faculty of Pharmacy, Division of Pharmacology and Pharmacotherapy, Regenerative pharmacology group, Drug Research Program |
| Jazyk: | angličtina |
| Předmět: |
Male
Pressure overload MOLECULAR TARGET SALIVARY-GLAND CANCER Gene Expression Rats Inbred WKY Rats Sprague-Dawley Rats Inbred SHR Gene expression Myocardial infarction STIMULATED CLONE-22 CARDIAC-HYPERTROPHY Cells Cultured Ventricular Remodeling ACTIVATED PROTEIN-KINASE Gene Transfer Techniques TGF-BETA Hypertensive heart disease 3. Good health Up-Regulation Cardiac hypertrophy TRANSCRIPTION FACTORS 317 Pharmacy Hypertension Female Signal transduction Cardiology and Cardiovascular Medicine Research Article Metoprolol Signal Transduction medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Heart failure Gene delivery Losartan Internal medicine medicine Animals RNA Messenger CELL Ventricular remodeling neoplasms Antihypertensive Agents Muscle Cells business.industry GROWTH-FACTOR-BETA Myocardium medicine.disease nervous system diseases Repressor Proteins Endocrinology Collagen Type III MYOCARDIAL-INFARCTION business |
| Zdroj: | BMC Cardiovascular Disorders |
| ISSN: | 1471-2261 |
| DOI: | 10.1186/s12872-015-0121-2 |
| Popis: | Background: The transforming growth factor (TGF)-beta is one of the key mediators in cardiac remodelling occurring after myocardial infarction (MI) and in hypertensive heart disease. The TGF-beta-stimulated clone 22 (TSC-22) is a leucine zipper protein expressed in many tissues and possessing various transcription-modulating activities. However, its function in the heart remains unknown. Methods: The aim of the present study was to characterize cardiac TSC-22 expression in vivo in cardiac remodelling and in myocytes in vitro. In addition, we used TSC-22 gene transfer in order to examine the effects of TSC-22 on cardiac gene expression and function. Results: We found that TSC-22 is rapidly up-regulated by multiple hypertrophic stimuli, and in post-MI remodelling both TSC-22 mRNA and protein levels were up-regulated (4.1-fold, P |
| Databáze: | OpenAIRE |
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