Clinical and angiographic results of angioplasty with a paclitaxel-eluting stent for unprotected left main coronary artery disease (a study of 101 consecutive patients)

Autor: Didier Carrié, Meyer Elbaz, H. Ouldzein, W. Zouaoui, Jacques Puel, R. Cherradi
Rok vydání: 2008
Předmět:
Male
Time Factors
medicine.medical_treatment
Coronary Angiography
Angioplastie
Restenosis
resténose
Hospital Mortality
Prospective Studies
Angioplasty
Balloon
Coronary
Aged
80 and over
Re-stenosis
Tronc coronaire gauche
Stent actif
Drug-Eluting Stents
General Medicine
Middle Aged
Treatment Outcome
Cardiovascular Diseases
Drug-eluting stent
Cardiology
Female
Cardiology and Cardiovascular Medicine
TIMI
Adult
medicine.medical_specialty
Acute coronary syndrome
Paclitaxel
Left Main Coronary Artery Stenosis
Coronary Restenosis
Left coronary artery
Internal medicine
medicine.artery
Angioplasty
Left main
medicine
Humans
Acute Coronary Syndrome
Aged
business.industry
Coronary Stenosis
Stent
Cardiovascular Agents
Length of Stay
medicine.disease
Surgery
Feasibility Studies
business
Platelet Aggregation Inhibitors
Zdroj: Archives of Cardiovascular Diseases. 101:11-17
ISSN: 1875-2136
DOI: 10.1016/s1875-2136(08)70249-3
Popis: Summary Background After coronary stenting with drug eluting stents, long-term clinical outcome of unprotected left main coronary artery disease is unknown, even large scale registries or randomised trials with coronary artery bypass graft are ongoing. Aims To report clinical and angiographic results of paclitaxel-eluting stent implantation for left main coronary artery stenosis (a series of 101 consecutive patients). Methods This report is a prospective study performed to evaluate the immediate and mid-term clinical and angiographic outcomes of patients undergoing paclitaxel-eluting stent (PES) implantation for unprotected left main coronary artery (LMCA) stenosis. From January 2004 to December 2005, 101 consecutive patients were stented with paclitaxel-eluting stents (the provisional T stenting technique followed by Kissing balloon for distal left main vessel disease). Results Mean age was 68.9 ± 11.07 years. 73.3% of patients were male. Acute coronary syndrome was present in 65% of patients, of whom 22.8% had ST elevation. Distal left main trunk lesions were present in 87.1% of cases. Three-vessel disease represented 7% of cases. Angiographic success was obtained in 97.03% of patients with an acute gain of 2.18 ± 0.53 mm. GPIIbIIIa inhibitors were used in only 8.9% of cases. Hospital stay was 7.6 ± 3.7 days. In-hospital complications were present in 7.9%, with a hospital mortality rate of 2%. At six month follow-up, the rate of target lesion revascularization (TLR) was 3%, and the rate for major adverse cardiac events (MACE) was 8.9%. Angiographic control was performed in 88.1% and a late loss of 0.1 mm (0.04–0.2 mm) was noted. Re-stenosis occurred in 4 patients (4.5% of cases). 4 patients (4%) died, including 2 from cardiac causes. Conclusion Paclitaxel-eluting stent implantation for unprotected left main coronary disease appears to be safe with high procedural success rate and a low re-stenosis rate at six month-follow-up.
Databáze: OpenAIRE
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