Effects of Propofol General Anesthesia on Olfactory Relearning
| Autor: | Pei Tang, Buwei Yu, Yan Xu, Li-Jie Jia, Yan Luo, Nicole R. Brandon |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Consciousness Transcription Genetic Amnesia Piriform Cortex Sensory system Anesthesia General Inhibitory postsynaptic potential Choice Behavior behavioral disciplines and activities Article Rats Sprague-Dawley 03 medical and health sciences Cognition 0302 clinical medicine Memory Basic Helix-Loop-Helix Transcription Factors Animals Learning Medicine Propofol Multidisciplinary business.industry GABAA receptor Olfactory Pathways 030104 developmental biology Odor Anesthesia Odorants Anesthetic medicine.symptom business Immediate early gene psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep33538 |
| Popis: | How general anesthesia interferes with sensory processing to cause amnesia remains unclear. Here, we show that activation of a learning-associated immediate early gene in rat olfactory cortices is uninterrupted by propofol, an intravenous general anesthetic with putative actions on the inhibitory GABAA receptors. Once learned under anesthesia, a novel odor can no longer re-activate the same high-level transcription programming during subsequent conscious relearning. Behavioral tests indicate that the animals’ ability to consciously relearn a pure odorant, first experienced under general anesthesia, is indeed compromised. In contrast, when a mixture of two novel odorants is first experienced under anesthesia and then relearned consciously in pairs with one of the components, the animals show a deficit in relearning only the component but not the mixture. Our results reveal a previously unknown mechanism of unconscious memory due to irreplaceable neuronal commitment under general anesthesia and support the notion that general anesthesia acts at stages beyond cellular coding to disrupt sensory integration for higher-order association. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|