Functional Neuroanatomy of Secondary Self-Injurious Behavior
| Autor: | Lynn Mubita, Hiromi Holt, Eileen A Choudhary, Steve W. Wu, Alaine C Keebaugh, Sudhakar Vadivelu, Donald L. Gilbert, Jesse Skoch, Kavan P Vadivelu, Sophie Peeters, Ellen Air |
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| Rok vydání: | 2018 |
| Předmět: |
Deep brain stimulation
Movement disorders Deep Brain Stimulation medicine.medical_treatment Dysfunctional family Pediatrics Basal Ganglia 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Animals Humans Effective treatment Clinical efficacy Movement Disorders business.industry Mental Disorders Brain General Medicine Neuromodulation (medicine) Neuroanatomy medicine.anatomical_structure Pediatrics Perinatology and Child Health Functional neuroanatomy Surgery Neurology (clinical) medicine.symptom business Self-Injurious Behavior Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Neurosurgery. 53:71-80 |
| ISSN: | 1423-0305 1016-2291 |
| DOI: | 10.1159/000485385 |
| Popis: | Background: Secondary self-injurious behavior (SSIB) is underreported and predominantly not associated with suicide. In both adults and children, SSIB can cause intractable self-harm and is associated with a variety of clinical disorders, particularly those involving dysfunctional motor control. Methods: We performed a literature review evaluating the clinical efficacy of deep-brain stimulation (DBS) as modulating SSIB observations and review current progress in preclinical SSIB animal studies. Results: Neuromodulation is an effective therapeutic option for several movement disorders. Interestingly, this approach is emerging as a potentially effective treatment for movement disorder-associated SSIB (secondary); however, it is important to understand the neuroanatomy, clinical appraisal, and outcome data when considering surgical therapy for SSIB. Conclusion: The current review examines the literature encompassing animal models and human case studies while identifying existing hypotheses from cytoarchitectonic-based targeting to neurotransmitter-based pathways. This review also highlights the need for awareness of an underrecognized pathology that may be amenable to DBS. |
| Databáze: | OpenAIRE |
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