Oxidative Stress and Nasal Polyposis: Does it Affect the Severity of the Disease?
| Autor: | Ozgul Topal, Selim S. Erbek, Sevsen Kulaksizoglu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Turkey Visual analogue scale Nasal congestion Nitric Oxide medicine.disease_cause Severity of Illness Index Gastroenterology chemistry.chemical_compound Nasal Polyps Malondialdehyde Internal medicine Severity of illness medicine Humans Immunology and Allergy Aged Eosinophil cationic protein rhinorrhea business.industry Eosinophil Cationic Protein General Medicine Middle Aged Oxidative Stress Otorhinolaryngology chemistry Disease Progression Quality of Life Nasal Lavage Female medicine.symptom Reactive Oxygen Species Tomography X-Ray Computed business Oxidation-Reduction Oxidative stress |
| Zdroj: | American Journal of Rhinology & Allergy. 28:e1-e4 |
| ISSN: | 1945-8932 1945-8924 |
| Popis: | Background Nasal polyposis (NP) is a chronic inflammatory disease and the waste products of this inflammation are reactive oxygen species composed of free radicals. Changes in oxidative status have already been revealed in NP. The aim of this study was to investigate the effect of oxidative status to the severity of the disease and the quality of life. Methods The study group included 24 patients with NP and 20 controls. The Turkish version of the Rhinosinusitis Disability Index, visual analog scale (VAS), polyp stage, computed tomography (CT) score, and the eosinophilic cationic protein (ECP) levels in nasal lavage (NAL) fluid were used to assess the severity of the disease. Malondialdehyde, nitric oxide (NO), and the total antioxidant status (TAS) levels in NAL fluids were measured representing the oxidative stress. Results NO values were correlated with nasal congestion (p = 0.031). TAS values were correlated with nasal obstruction (p = 0.039). ECP values showed correlation with all the nasal obstruction (p = 0.003), congestion (p = 0.009), rhinorrhea (p = 0.009), and VAS scores (p = 0.039). Conclusion In NP, ECP levels detected in NAL fluid were significantly high and were correlated with the severity of the disease. Moreover, the severity of oxidative stress, in the forms of TAS and NO, is significantly correlated with the severity of the nasal obstruction and congestion, respectively. |
| Databáze: | OpenAIRE |
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