Bioorganic synthesis, characterization and evaluation of a natural phenolic lipid
| Autor: | Dileep K Veeragoni, Juliya Johny, Venkateshwarlu Kontham, Sunil Misra, Shiva Shanker Kaki |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Antioxidant DPPH Cytotoxicity medicine.medical_treatment lcsh:Biotechnology 01 natural sciences Applied Microbiology and Biotechnology Article Ferulic acid 03 medical and health sciences chemistry.chemical_compound 010608 biotechnology lcsh:TP248.13-248.65 medicine Glycerol Monoacylglycerol Organic chemistry Lipase Phenolic lipid 030304 developmental biology 0303 health sciences biology Antimicrobial biology.organism_classification Monoacylglycerol lipase chemistry biology.protein lipids (amino acids peptides and proteins) Candida antarctica Biotechnology |
| Zdroj: | Biotechnology Reports, Vol 24, Iss, Pp-(2019) Biotechnology Reports |
| Popis: | Highlights • First bioorganic synthesis of a novel phenolic lipid isolated from natural source. • The phenolic lipid was synthesized following a chemo-enzymatic approach. • Lipase-catalyzed transformation was employed in the synthesis. • The prepared phenolic lipid exhibited excellent antioxidant potential. • The prepared phenolic lipid could have great potential in food and cosmetic formulations. The first synthesis of a phenolic natural monoacylglycerol (1- [11-(ferulyloxy) undecanoyl)] glycerol) was carried out by bioorganic synthesis starting from ferulic acid. The synthetic route of the target lipidic compound was designed involving a chemo-enzymatic approach using immobilized Candida antarctica lipase as biocatalyst in two of the steps conducted in organic medium. The prepared lipidic compound was characterized by using spectral data and evaluated for antimicrobial, antioxidant and cytotoxic studies to examine its potential. The synthesized compound showed moderate antimicrobial activity and showed very good antioxidant activity in DPPH radical scavenging assay and also in oxidation inhibition in soybean oil by differential scanning calorimetry. The cytotoxic studies of the synthetic lipid showed promising activity against A549 and HeLa cancer cell lines with IC50 values of 9.102 and 9.886 μM respectively. The prepared compound can be useful in designing novel phenolic lipids with potential applications in cosmetic and biomedical fields. |
| Databáze: | OpenAIRE |
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