Audiological Patterns in Patients with Autoimmune Hearing Loss
| Autor: | G. Dimas, Michalis Daniilidis, George Psillas, Thomas Tegos, Jiannis Constantinidis, Paris Binos |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Anti-nuclear antibody Physiology Hearing loss Hearing Loss Sensorineural Deafness Logistic regression Medical and Health Sciences Hearing Loss Bilateral Speech and Hearing Autoimmune disease Inner ear Fluctuating hearing Humans Tone audiometry Medicine Retrospective Studies Human leukocyte antigen business.industry Audiogram Hearing Loss Sudden medicine.disease Sensory Systems Otorhinolaryngology Concomitant Vertigo Steroids Sensorineural hearing loss Clinical Medicine medicine.symptom business Tinnitus |
| Zdroj: | Audiology and Neurotology. 27:336-346 |
| ISSN: | 1421-9700 1420-3030 |
| DOI: | 10.1159/000518694 |
| Popis: | Introduction: The aim of this study was to illustrate clinical and audiological patterns of hearing impairment in patients with autoimmune hearing loss (AIHL). Methods: Fifty-three patients with AIHL were retrospectively recruited, and a tapering schema of steroid treatment was administered in all these patients. The diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, sudden (sensorineural hearing loss [SSHL]), fluctuating, or quickly progressing (Results: The onset of AIHL was mainly progressive (49%), followed by SSHL (39.6%) or fluctuating (11.3%). The pure-tone audiogram showed more commonly a downsloping pattern (42.6% of ears), but also an upsloping, flat, cookie-bite, or inverse cookie-bite shape. Bilateral progressive AIHL was more frequently simultaneous (23 patients) than heterochronous (4 patients). Nineteen patients (35.8%) showed a favorable response to steroid therapy. The presence of recurrent, bilateral SSHL versus recurrent, unilateral SSHL had statistically negative effect on hearing recovery (OR = 0.042, p < 0.05). The heterochronous bilateral SSHL may have better prognosis than simultaneous bilateral SSHL (OR = 10.000, p = 0.099). The gender, age, concomitant autoimmune disease, high ANA, HLA alleles, tinnitus, and vestibular symptoms had no statistical effect on a favorable outcome of AIHL. Conclusions: A bilateral, simultaneous, and progressive hearing loss combined with downsloping audiogram occurred more often in patients with AIHL. Bilateral simultaneous SSHL with recurrences represents the worse prognostic form of AIHL. |
| Databáze: | OpenAIRE |
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