Dual TMPRSS2:ERG Fusion in a Patient with Lung and Prostate Cancers
| Autor: | Annalisa Altimari, Andrea Ardizzoni, Francesco Massari, Elisabetta Nobili, Michelangelo Fiorentino, Francesca Giunchi, Elisa Gruppioni |
|---|---|
| Přispěvatelé: | Giunchi, Francesca, Massari, Francesco, Altimari, Annalisa, Gruppioni, Elisa, Nobili, Elisabetta, Fiorentino, Michelangelo, Ardizzoni, Andrea |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
genetic structures Clinical Biochemistry Case Report urologic and male genital diseases TMPRSS2:ERG fusion TMPRSS2 Metastasis 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate medicine Lung cancer Lymph node lcsh:R5-920 business.industry Cancer respiratory system prostate cancer medicine.disease eye diseases lung cancer n/a 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research next-generation sequencing sense organs lcsh:Medicine (General) business Erg |
| Zdroj: | Diagnostics Diagnostics, Vol 10, Iss 1109, p 1109 (2020) |
| ISSN: | 2075-4418 |
| DOI: | 10.3390/diagnostics10121109 |
| Popis: | The TMPRSS2:ERG fusion is considered prostate specific and has been rarely described in other tumors. We describe the case of a patient who developed lung and prostate cancers, both harboring the TMPRSS2:ERG fusion. The patient developed a cancer of the prostate with lymph node metastases and after two years a nodule of the thoracic wall. The histology and immunohistochemical profile of the two tumors were typical of prostate and lung cancers. The presence of the TMPRSS2:ERG fusion was demonstrated by next-generation sequencing on both malignancies, leading to the assumption that the lung nodule was a metastasis from the prostate cancer. The patient failed to respond to antiandrogen therapy, while chemotherapy for lung cancer led to a significant objective response. To our knowledge, this is the first case of a lung cancer harboring the TMPRSS2:ERG fusion, widening the spectrum of lung cancer-associated molecular alterations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|