Studies of antigens inPlasmodium yoelii
| Autor: | Lindsey J. Panton, D. Walliker, G. Knowles |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Genetic Markers
Plasmodium Virulence Gene mutation Isozyme Epitopes Mice Antigen Animals Parasite hosting Gene Crosses Genetic Recombination Genetic Genetics biology biology.organism_classification Virology Phenotype Mice Inbred C57BL Infectious Diseases Genes Animal Science and Zoology Parasitology Immunoelectrophoresis Two-Dimensional Plasmodium yoelii |
| Zdroj: | Parasitology. 89:27-34 |
| ISSN: | 1469-8161 0031-1820 |
| Popis: | SummaryThe inheritance of an antigen designated Py-1 in the rodent malaria parasitePlasmodium yoeliihas been investigated. A cross was made between 2 lines differing in the electrophoretic mobility and quantity of Py-1 detected by crossed immunoelectrophoresis. In 10 clones isolated from the progeny of the cross the level of Py-1 always correlated with the virulence of the infection and it was concluded that these characters were different phenotypic effects of the same gene mutation. The electrophoretic mobility of Py-1 segregated independently of the virulence character and was therefore controlled by a different gene. These two antigenic markers also recombined with isoenzyme and drug-sensitivity characters distinguishing the parent lines. |
| Databáze: | OpenAIRE |
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