Correlation of Morphology and Function of Flecks Using Short-Wave Fundus Autofluorescence and Microperimetry in Patients With Stargardt Disease
| Autor: | J.M.M. Groenewoud, Patty P.A. Dhooge, Nathalie M. Bax, B. Jeroen Klevering, Esmee H. Runhart, Stanley Lambertus, Carel B. Hoyng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Zinc Phosphate Cement medicine.medical_specialty Longitudinal study Fundus Oculi short-wavelength autofluorescence (SW-AF) imaging Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Biomedical Engineering autofluorescence Article Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] Lesion 03 medical and health sciences chemistry.chemical_compound All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Ophthalmology Medical imaging Humans Stargardt Disease Medicine Longitudinal Studies Prospective Studies Fluorescein Angiography ATP-binding cassette transporter A4 (ABCA4) business.industry Retinal stargardt disease (STGD) medicine.disease Intensity (physics) Stargardt disease Autofluorescence 030104 developmental biology chemistry microperimetry 030221 ophthalmology & optometry Visual Field Tests medicine.symptom business Microperimetry Tomography Optical Coherence |
| Zdroj: | Translational Vision Science & Technology, 10, 3 Translational Vision Science & Technology, 10 Translational Vision Science & Technology |
| ISSN: | 2164-2591 |
| Popis: | Purpose The purpose of this study was to evaluate the functional relevance of longitudinal changes in hyperautofluorescent areas and flecks in Stargardt disease (STGD1) using short-wavelength autofluorescence (SW-AF) imaging. Methods In this prospective, longitudinal study, 31 patients with STGD1 (56 eyes) underwent microperimetry (MP) and SW-AF imaging twice in 3 to 5 years. A total of 760 MP test points were included in the statistical analysis based on stable fixation and accurate alignment of SW-AF and MP. Autofluorescence intensity was qualitatively assessed in all MP test points. Small circumscriptive hyperautofluorescent lesions were defined as flecks. Longitudinal imaging characteristics observed on SW-AF were classified into the following categories: appearing, disappearing, and stable flecks, stable hyperautofluorescent, and stable background autofluorescence. The relationship between SW-AF intensity changes and MP changes was analyzed using a linear mixed model corrected for baseline sensitivity. Results Retinal sensitivity declined most in locations without change in SW-AF intensity. Functional decline per year was significantly larger in flecks that disappeared (−0.72 ± 1.30 dB) compared to flecks that appeared (−0.34 ± 0.65 dB), if baseline sensitivity was high (≥10 dB; P < 0.01). The correlation between the change observed on SW-AF and the sensitivity change significantly depended on the sensitivity at baseline (P = 0.000). Conclusions Qualitative longitudinal assessment of SW-AF poorly reflected the retinal sensitivity loss observed over the course of 3 to 5 years. Translational Relevance When aiming to assess treatment effect on lesion level, a multimodal end point including MP focused on hyperautofluorescent lesions appears essential but needs further studies on optimizing MP grids, eye-tracking systems, and alignment software. |
| Databáze: | OpenAIRE |
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