Clavukoellians G–K, New Nardosinane and Aristolane Sesquiterpenoids with Angiogenesis Promoting Activity from the Marine Soft Coral Lemnalia sp
| Autor: | Guoqiang Li, Ping-Jyun Sung, Ping-Lin Li, Hui Liu, Xiangchao Luo, Qi Wang, Xuli Tang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
China
South china Magnetic Resonance Spectroscopy Stereochemistry Angiogenesis Pyridines Coral VEGF receptors Pharmaceutical Science Neovascularization Physiologic nardosinane Sesquiterpene 01 natural sciences Article Green fluorescent protein Lemnalia sp Animals Genetically Modified chemistry.chemical_compound Drug Discovery Animals aristolane lcsh:QH301-705.5 Pharmacology Toxicology and Pharmaceutics (miscellaneous) Zebrafish Biological Products biology Molecular Structure 010405 organic chemistry sesquiterpenoid Anthozoa 0104 chemical sciences clavukoellian 010404 medicinal & biomolecular chemistry lcsh:Biology (General) chemistry Models Animal lemnalia sp biology.protein Blood Vessels Phthalazines Angiogenesis Inducing Agents angiogenesis promoting activity Sesquiterpenes |
| Zdroj: | Marine Drugs Marine Drugs, Vol 18, Iss 3, p 171 (2020) Volume 18 Issue 3 |
| ISSN: | 1660-3397 |
| Popis: | The chemical examination of the marine soft coral Lemnalia sp., collected at the Xisha islands in the South China Sea, resulted in the isolation of four new nardosinane-type sesquiterpenoids, namely clavukoellians G&ndash J (1&ndash 4), and one new aristolane sesquiterpene, namely clavukoellian K (5), together with five known compounds, 6&ndash 10. The structure elucidation of the isolated natural products was based on various spectroscopic techniques including HRESIMS and NMR, while their absolute configurations were resolved on the basis of comparisons of the ECD spectra with the calculated ECD data. The isolated new compounds 1&ndash 5 were evaluated for their anti- and pro- angiogenesis activities in a transgenic fluorescent zebrafish (Tg(vegfr2:GFP)) model. Quantitative analysis revealed that compound 5 displayed pro-angiogenesis activity in a PTK787-induced vascular injury zebrafish model at 2.5 &mu M. Data showed that compound 5 significantly promoted the angiogenesis in a dose-dependent manner. |
| Databáze: | OpenAIRE |
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