Assessment of medication use during pregnancy by Web-based questionnaires, pharmacy records and serum screening

Autor: Eugène van Puijenbroek, Saskia Vorstenbosch, Lutea A.A. de Jong, Nel Roeleveld, Bernke te Winkel, Marleen M.H.J. van Gelder, André L. M. Verbeek, Erik J.H. Olyslager
Přispěvatelé: PharmacoTherapy, -Epidemiology and -Economics, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
Rok vydání: 2019
Předmět:
Questionnaires
INFORMATION
paracetamol
LC-TOF-MS
dermatological procedure
010501 environmental sciences
Toxicology
01 natural sciences
Medical Records
Pharmacy records
online system
DESIGN
Pregnancy
venlafaxine
Surveys and Questionnaires
blood analysis
clinical pharmacy
meclozine
drug monitoring
0303 health sciences
Medication use
adult
web browser
desloratadine
article
prednisolone
cohort analysis
time of flight mass spectrometry
Women's cancers Radboud Institute for Health Sciences [Radboudumc 17]
female
Pharmaceutical Preparations
mesalazine
AGREEMENT
Gestation
blood sampling
Serum screening
paroxetine
medicine.medical_specialty
drug exposure
MATERNAL RECALL
first trimester pregnancy
salazosulfapyridine
DRUG-USE
medical record
VALIDATION
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
03 medical and health sciences
PRIDE Study
short course therapy
gestation period
Internal medicine
medicine
Humans
liquid chromatography
human
EXPOSURE
fexofenadine
music
030304 developmental biology
0105 earth and related environmental sciences
drug use
Pharmacies
Internet
business.industry
questionnaire
Gold standard
music.record_label
Serum samples
medicine.disease
Drug Utilization
Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]
drug blood level
inhalational drug administration
Self Report
business
chronic disease
Blood sampling
Zdroj: Reproductive Toxicology, 84, 93-97. HANLEY & BELFUS-ELSEVIER INC
Reproductive Toxicology, 84, 93-97
Reproductive Toxicology, 84, pp. 93-97
ISSN: 0890-6238
Popis: Contains fulltext : 202694.pdf (Publisher’s version ) (Open Access) OBJECTIVE: To compare assessment of early pregnancy medication exposure using three methods of data collection. METHODS: Serum samples were obtained from 752 women participating in the PRegnancy and Infant DEvelopment (PRIDE) Study before gestational week 17. For 52 women using medication at the date of blood sampling according to Web-based questionnaires or pharmacy records, we analysed serum samples using untargeted liquid chromatography time-of-flight spectrometry. RESULTS: Medication was detected in 18 serum samples (35%). Medications taken orally for chronic conditions reported in the questionnaire were detected in serum and vice versa. Pharmacy records did not identify additional exposed women, but missed exposure in 5 women mainly due to unavailability. We observed substantial discordance between the three methods for inhaled medication, dermatological preparations, and medications for short-term use, which went often undetected in serum. CONCLUSIONS: It remains challenging to assess medication use in large-scale studies as no 'gold standard' is currently available.
Databáze: OpenAIRE
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