Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021
| Autor: | Grace M. Aldrovandi, Kathleen Mulligan, Adrienne Rollie, Fan Li, Nicole H. Tobin, John W. Sleasman, Alexandra Ruan |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Bone density Adolescent Cross-sectional study CD14 Osteoporosis Physiology sVCAM HIV Infections bone Article 03 medical and health sciences Young Adult 0302 clinical medicine Absorptiometry Photon Sex Factors macrophage activation Bone Density Antiretroviral Therapy Highly Active medicine Macrophage Humans Pharmacology (medical) 030212 general & internal medicine Young adult Interleukin 6 Bone mineral IL-6 biology business.industry Puerto Rico HIV Macrophage Activation medicine.disease sCD14 030112 virology Spine United States Bone Diseases Metabolic Infectious Diseases Cross-Sectional Studies Immunology biology.protein Female business |
| Zdroj: | Ruan, A; Tobin, NH; Mulligan, K; Rollie, A; Li, F; Sleasman, J; et al.(2016). Brief Report: Macrophage Activation in HIV-Infected Adolescent Males Contributes to Differential Bone Loss by Sex: Adolescent Trials Network Study 021. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 72(4), 372-375. doi: 10.1097/QAI.0000000000000953. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1v05r3px |
| ISSN: | 1944-7884 |
| DOI: | 10.1097/QAI.0000000000000953. |
| Popis: | Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than females. Of eleven biomarkers assessed by sex and HIV-status, HIV-infected males had increased levels of soluble CD14 which inversely correlated with bone mineral content and bone mineral density measures, suggesting macrophage activation as a possible mechanism of differential bone loss. |
| Databáze: | OpenAIRE |
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