Vitamin D and inflammation: evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio
| Autor: | Adalet Ozcicek, Nergis Akbas, Adem Güngör, Emin Murat Akbas, Murat Polat, Seda Askin |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Parathyroid hormone vitamin D 030204 cardiovascular system & hematology endothelial dysfunction vitamin D deficiency Bone remodeling 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Clinical Research Internal medicine Vitamin D and neurology Medicine 030212 general & internal medicine Neutrophil to lymphocyte ratio Creatinine medicine.diagnostic_test business.industry Albumin Complete blood count General Medicine medicine.disease body regions Endocrinology chemistry inflammation business |
| Zdroj: | Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| Popis: | Introduction Association of vitamin D, inflammation and endothelial dysfunction, beside the classic bone metabolism disorders, may explain the pathogenesis of numerous diseases associated with vitamin D deficiency. While large numbers of reports support the relationship of vitamin D with inflammation, several reports fail to confirm this relationship. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are novel and inexpensive markers of inflammation that can be studied in all centers. The goal of this study was to investigate the association between 25-hydroxy vitamin D (25(OH)D) and inflammation with the novel inflammatory markers NLR and PLR. Material and methods This study was performed retrospectively. Results of the simultaneously performed 25(OH)D, parathyroid hormone, albumin, calcium, phosphorus, alkaline phosphatase and creatinine level measurements and complete blood count were recorded. The data of 4120 patients were included in the study. Results Between vitamin D deficient and non-deficient groups there were significant differences in PLR (p < 0.001) and NLR (p = 0.001). Vitamin D had a significant negative correlation with PLR (p < 0.001) and NLR (p < 0.001). Multiple regression analysis indicated that 25(OH)D was independently and negatively correlated with PLR (OR = 0.994, 95% CI 0.991–0.998, p = 0.02). Conclusions Platelet-to-lymphocyte ratio and NLR were significantly associated with 25(OH)D levels, and PLR was found to be an independent predictor of 25(OH)D levels. Our study revealed an inverse association of vitamin D levels and inflammation with these inexpensive and universally available markers. |
| Databáze: | OpenAIRE |
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