The Mechanical Autophagy as a Part of Cellular Immunity; Facts and Features in Treating the Medical Disorders
| Autor: | Farha A El-Chennawi, Dalia Mohamed, Bhgat El-Fikiy, Ahmed I. Abd El Maksoud, Doaa D. Mohamed, Khaled A. Elawdan, Hany Khalil, Amira Abd ElHady, Ibrahim H. El-Sayed |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cellular immunity Physiological function Immunity Cellular business.industry Immunology Autophagy Cancer therapy General Medicine medicine.disease_cause 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Neoplasms medicine Humans Energy source business Neuroscience Cell survival Coronavirus |
| Zdroj: | Immunological investigations. 51(2) |
| ISSN: | 1532-4311 |
| Popis: | Autophagy is a cellular housekeeping process that incorporates lysosomal-degradation to maintain cell survival and energy sources. In recent decades, the role of autophagy has implicated in the initiation and development of many diseases that affect humanity. Among these diseases are autoimmune diseases and neurodegenerative diseases, which connected with the lacking autophagy. Other diseases are connected with the increasing levels of autophagy such as cancers and infectious diseases. Therefore, controlling autophagy with sufficient regulators could represent an effective strategy to overcome such diseases. Interestingly, targeting autophagy can also provide a sufficient method to combat the current epidemic caused by the ongoing coronavirus. In this review, we aim to highlight the physiological function of the autophagic process to understand the circumstances surrounding its role in the cellular immunity associated with the development of human diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|