Microwave-assisted synthesis of 2,8-di(alkyl/aryl)-4,6-dichloro-2H,8H-pyrano[3,2-g] chromene-3,7-dicarbaldehydes and their antimicrobial activity
| Autor: | Venkata Ramana Reddy Chittireddy, Dongamanti Ashok, Rupireddy Venkataramana, Kudle Karunakar Rao |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
antimicrobial activity Aryl General Chemistry Antimicrobial Pyrrolidine lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 Elemental analysis Reagent Microwave irradiation Vilsmeier-Haack reagent Organic chemistry Piperidine bischromanone: bischromene microwave irradiation Alkyl |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 84, Iss 4, Pp 355-364 (2019) |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | A series of 2,8-di(alkyl/aryl)-substituted bischromanone derivatives were synthesized in one pot from 4,6-diacetylresorcinol and aliphatic/aromatic aldehydes in the presence of pyrrolidine/piperidine under conventional heating and microwave irradiation. The 2,8-di(alkyl/aryl)-substituted bischromanones were converted into a new series of 4,6-dichloro-3,7-diformyl-2,8-di(alkyl/aryl)-substituted bischromenes using the Vilsmeier?Haack reagent. The structures of the compounds were established based on elemental analysis, IR, 1H-NMR, 13C- -NMR and LC?MS spectral data. All the synthesized compounds were evaluated for their antimicrobial activity. Some of the compounds showed very good activity compared to standard drugs against all the tested pathogenic bacteria and fungi. |
| Databáze: | OpenAIRE |
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