Toward the Synthesis and Biological Screening of a Cyclotetrapeptide from Marine Bacteria
| Autor: | Rajiv Dahiya, Hemendra Gautam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Aquatic Organisms
Stereochemistry Diginea sp Oceans and Seas Pharmaceutical Science Peptide biological activity Microbial Sensitivity Tests cyclic tetrapeptide Peptides Cyclic Article chemistry.chemical_compound natural product synthesis marine bacteria Halisarca ectofibrosa Pseudoalteromonas Marine bacteriophage Parasitic Sensitivity Tests Pseudomonas Drug Discovery Animals Pharmacology Toxicology and Pharmaceutics (miscellaneous) lcsh:QH301-705.5 chemistry.chemical_classification Anthelmintics Oligopeptide Dipeptide biology Tetrapeptide Biological activity Dipeptides biology.organism_classification Seaweed Anti-Bacterial Agents Porifera chemistry lcsh:Biology (General) Cyclization Oligopeptides |
| Zdroj: | Marine Drugs Marine Drugs, Vol 9, Iss 1, Pp 71-81 (2010) Marine Drugs; Volume 9; Issue 1; Pages: 71-81 |
| ISSN: | 1660-3397 |
| Popis: | The first synthesis of a naturally occurring tetrapeptide cyclo-(isoleucyl-prolyl-leucyl- alanyl) has been achieved using a solution-phase technique via coupling of dipeptide segments Boc-l-Pro-l-Leu-OH and l-Ala-l-Ile-OMe. Deprotection of the linear tetrapeptide unit and its subsequent cyclization gave a cyclopeptide, identical in all aspects to the naturally occurring compound. Bioactivity results indicated the antifungal and antihelmintic potential of the synthesized peptide against pathogenic dermatophytes and earthworms. |
| Databáze: | OpenAIRE |
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