Skeletal fluorosis: Histomorphometric findings
| Autor: | Pascale Chavassieux, Pierre J. Meunier, Georges Boivin, Charles A. Baud, Marie-Claire Chapuy |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Biopsy Endocrinology Diabetes and Metabolism Poison control Dentistry chemistry.chemical_compound Osteosclerosis Skeletal fluorosis Internal medicine medicine Humans Orthopedics and Sports Medicine Aged Aged 80 and over business.industry Osteoid Middle Aged medicine.disease Apposition Bone ash Endocrinology medicine.anatomical_structure chemistry Female Cortical bone Bone Diseases business Cancellous bone Fluoride Poisoning |
| Zdroj: | Journal of Bone and Mineral Research. 5:S185-S189 |
| ISSN: | 0884-0431 |
| DOI: | 10.1002/jbmr.5650051382 |
| Popis: | Histomorphometric analysis of undecalcified sections was performed in transiliac biopsy cores taken from 29 patients (16 men, 13 women, aged 51 +/- 17 years) suffering from skeletal fluorosis due to chronic exposure to fluoride. The origin of the exposure, known in 20 patients, was either by water (endemic or sporadic), or industrial, or in a few cases iatrogenic. Measured on calcified bone using a specific ion electrode, bone fluoride content was significantly high in each specimen (mean +/- SD: 0.79 +/- 0.36% of bone ash) as compared to control values (less than 0.10%). The radiologically evident osteosclerosis observed in each patient was confirmed by the significant increase of cancellous bone volume (40.1 +/- 11.2 vs. 19.0 +/- 2.8% in controls, p less than 0.0001). There were significant increases in cortical width (1292 +/- 395 vs. 934 +/- 173 microns, p less than 0.0001) and porosity (14.4 +/- 6.4 vs. 6.5 +/- 1.7%, p less than 0.002), but without reduction of cortical bone mass. Osteoid parameters were significantly increased in fluorotic patients. The increase in cancellous osteoid perimeter was almost threefold greater than that noted in cancellous eroded perimeter. The fluorotic group had a greater number of osteoblasts than controls, with a very high proportion of flat osteoblasts. In 15 patients doubly labeled with tetracycline, the mineral apposition rate was significantly decreased, while mineralization lag time significantly increased. Bone formation rate and adjusted apposition rate were significantly decreased in skeletal fluorosis. Cancellous wall width was normal in fluorosis but the formation period and active formation period were significantly increased.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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