Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains
| Autor: | Dimitris Mossialos, D. Tsakogiannis, Panayotis Markoulatos, Z. Kyriakopoulou, Grigoris D. Amoutzias, T.G. Dimitriou |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Untranslated region Echovirus Five prime untranslated region viruses 030106 microbiology Echovirus Infections Genome Viral Biology Serogroup medicine.disease_cause Genome Evolution Molecular Viral Proteins 03 medical and health sciences Phylogenetics Virology medicine Humans Phylogeny Recombination Genetic Genetics Phylogenetic tree Strain (biology) virus diseases General Medicine Enterovirus B Human 030104 developmental biology RNA Viral 5' Untranslated Regions Recombination |
| Zdroj: | Archives of Virology. 163:365-375 |
| ISSN: | 1432-8798 0304-8608 |
| DOI: | 10.1007/s00705-017-3600-1 |
| Popis: | Recombination has been recognized as a major mechanism of evolution in enteroviruses. The Echovirus 30 (E-30) strain Gior was sequenced and phylogenetically compared to all available E-30 sequences to detect recombination events between the 5΄UTR and VP1 genomic regions. The comparison of phylogenetic trees of the 5΄UTR and VP1 revealed incongruences concerning strains, lineages and sub-lineages. Comparative analysis of 62 E-30 sub-genomic sequences revealed six different recombination events that almost all occurred in the same region, having a start point in the 3΄end of the 5΄ UTR and end point in VP4. The only exception was the sub-lineage of Gior for which both borders of recombination were located in the 5΄UTR. These results describe for the first time recombination events in this region in circulating EV-B strains, revealing the exact points of these recombination events, highlighting the impact of such events on the evolution and epidemiology of enteroviruses. |
| Databáze: | OpenAIRE |
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