The site of infection and ethnicity of the patient influence the biological pathways to HPV-induced mucosal cancer
| Autor: | Richard A. Scolyer, Wei Li, Christopher Dalrymple, Jonathan Carter, Barbara Rose, Carol H. Thompson, Jihong Liu, Christopher J. O'Brien, Yvonne E. Cossart |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Cyclin-Dependent Kinase Inhibitor p21 Oncology China medicine.medical_specialty Pathology Tonsillar Neoplasms Uterine Cervical Neoplasms Cell Cycle Proteins Biology medicine.disease_cause Retinoblastoma Protein Pathology and Forensic Medicine Internal medicine medicine Carcinoma Humans Tonsil cancer Cyclin D1 Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Aged Neoplasm Staging Aged 80 and over Cervical cancer Tumor Suppressor Proteins Papillomavirus Infections Australia Cancer Middle Aged medicine.disease biology.organism_classification Immunohistochemistry Koilocyte medicine.anatomical_structure Tonsil Carcinoma Squamous Cell Female Tumor Suppressor Protein p53 Carcinogenesis Cyclin-Dependent Kinase Inhibitor p27 |
| Zdroj: | Modern Pathology. 17:1031-1037 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/modpathol.3800155 |
| Popis: | High-risk human papillomaviruses are the causative agents of cervical cancer and are also believed to be aetiologically involved in a subset of squamous cell carcinomas of the head and neck region, especially the tonsil. Cervical cancers arise through disruption of the pathways of p53 and the product of the retinoblastoma gene by the human papillomavirus oncoproteins E6 and E7. It is generally assumed that the same pathways are involved in human papillomavirus-induced carcinogenesis at other mucosal surfaces. However, the patterns of expression of cell cycle proteins targeted by human papillomavirus E6 and E7 in cancers from different anatomic sites have been inconsistent, due to either biologic or technological factors. In this study, 73 human papillomavirus, 16-positive cervical squamous cell carcinomas (35 from Australian and 38 from Chinese women) were analysed for the expression of p53, pRb, p16(INK4A), p21(CIP1/WAF1), p27(KIP1) and cyclin D1 by semiquantitative immunohistochemistry. Cervical cancers from Chinese women were found to be significantly more likely to overexpress p53, pRb, p21 and p27 than their Australian counterparts. These findings were compared with those from 31 human papillomavirus 16-positive tonsillar squamous cell carcinomas, all of Australian origin, tested using the same methodology. Comparisons of the tonsillar and combined cervical data showed that tonsillar cancers were significantly more likely to be p53-positive, whereas cervical cancers were significantly more likely to overexpress pRb, p16 and p27. When the tonsillar data were compared with cervical data from Australian women, the associations for p53 and pRb remained. These findings represent new evidence that the molecular pathways to human papillomavirus-induced mucosal cancer may be influenced by anatomic location and ethnicity. |
| Databáze: | OpenAIRE |
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