The Importance of Baseline Screening Investigations and Modified Severity Weighted Assessment Tool in Patients with Early Stage Mycosis Fungoides: A Four-year Retrospective Study
| Autor: | Gülsüm Özet, Buket Sahin, Neslihan Akdogan, Mesude Falay, Pınar Uysal, Başak Yalçin |
|---|---|
| Jazyk: | turečtina |
| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Mycosis fungoides business.industry Early-stage mycosis fungoides Retrospective cohort study Dermatology lcsh:RL1-803 medicine.disease prognostic biomarkers screening tests Modified Severity Weighted Assessment Tool medicine lcsh:Dermatology In patient Stage (cooking) business Baseline (configuration management) |
| Zdroj: | Turk Dermatoloji Dergisi, Vol 13, Iss 1, Pp 1-7 (2019) |
| ISSN: | 1308-5255 1307-7635 |
| Popis: | Objective:The present study aims to evaluate the prognosis and response to treatment relationship of baseline clinical and hematological parameters including eosinophil counts, neutrophil/lymphocyte ratio, levels of lactate dehydrogenase (LDH) and beta-2 microglobulin, flow cytometry and initial modified Severity Weighted Assessment Tool (mSWAT) scores in patients with mycosis fungoides (MF).Methods:Medical records of 112 patients with the diagnosis of early-stage MF were examined retrospectively. Data of the patient and disease characteristics, and baseline laboratory tests were reviewed and evaluated in terms of stage and treatment response.Results:In this study, patients were classified into two groups: responders and non-responders. Complete and partial responses were observed in 79 (70%) patients. Eight patients (7%) developed relapse in the follow-up period. In the staging groups (IA, IB, IIA), the frequency of elevated beta-2 microglobulin was different among all parameters. When the results were compared based on clinical responsiveness, until the time to diagnosis was significantly longer in non-responder patients than responders. High mSWAT scores, elevated beta-2 microglobulin and LDH levels, and plaque-type lesions were more frequent in non-responder patients.Conclusion:Our study demonstrates that extensive screening tests may not be very meaningful in patients with early-stage MF. mSWAT scores, beta-2 microglobulin, and LDH tests should be evaluated as useful measurements in prediction the response to treatment. |
| Databáze: | OpenAIRE |
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