Low target-INR anticoagulation is safe in selected aortic valve patients with the Medtronic Open Pivot mechanical prosthesis: long-term results of a propensity-matched comparison with standard anticoagulation
| Autor: | Yves Van Belleghem, Yves Taeymans, Michel De Pauw, Thierry Bové, Guido Van Nooten, Katrien François, Frank Caes |
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| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Aortic valve Male medicine.medical_specialty Time Factors Heart Valve Diseases 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Postoperative Complications Aortic valve replacement Belgium Risk Factors Internal medicine Thromboembolism medicine Humans Sinus rhythm 030212 general & internal medicine Heart valve Propensity Score Heart Valve Prosthesis Implantation business.industry Incidence Anticoagulants Odds ratio Middle Aged medicine.disease Prognosis Confidence interval Surgery Survival Rate Regimen medicine.anatomical_structure Aortic Valve Cardiology Female Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 24(6) |
| ISSN: | 1569-9285 |
| Popis: | OBJECTIVES To investigate the long-term results of a low international normalized ratio (INR)-anticoagulation program in selected patients after aortic valve replacement (AVR) with the Medtronic Open Pivot mechanical heart valve (OPMHV). METHODS From January 1993 to December 2012, 909 OPMHV valves were used for single AVR. Patients with preserved sinus rhythm and left ventricular function (Low-INR, n = 552), were managed to an INR of 1.5-2.5 and compared to patients (Standard-INR, n = 357) treated with standard anticoagulation (INR 2.5-3.5). Long-term outcome was analysed for survival and valve-related events, on propensity score matched pairs of 169 patients/group. RESULTS Within a follow-up cumulating 3096 patient-years, 10- and 15-year survival was significantly better for Low-INR patients: 79% and 63% vs 63% and 34% ( P |
| Databáze: | OpenAIRE |
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