Co(II), Ni(II) and Cu(II) complexes with coumarin-8-yl Schiff-bases: Spectroscopic, in vitro antimicrobial, DNA cleavage and fluorescence studies
| Autor: | Sangamesh A. Patil, Vinod H. Naik, Ajaykumar D. Kulkarni, Prema S. Badami, Shrishila N. Unki |
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| Rok vydání: | 2011 |
| Předmět: |
Antifungal Agents
Magnetic Resonance Spectroscopy Spectrophotometry Infrared Metal ions in aqueous solution Microbial Sensitivity Tests Photochemistry medicine.disease_cause Analytical Chemistry Metal chemistry.chemical_compound Coordination Complexes Coumarins Nickel medicine DNA Cleavage DNA Fungal Instrumentation Escherichia coli Schiff Bases Spectroscopy Molecular Structure biology Aspergillus niger Electron Spin Resonance Spectroscopy Cobalt Coumarin biology.organism_classification Fluorescence Tautomer Atomic and Molecular Physics and Optics Anti-Bacterial Agents chemistry visual_art visual_art.visual_art_medium Copper DNA Nuclear chemistry |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 79:1128-1136 |
| ISSN: | 1386-1425 |
| Popis: | A new series of Co(II), Ni(II) and Cu(II) complexes of the type ML·2H 2 O of Schiff-bases derived from m-substituted thiosemicarbazides and 8-acetyl-7-hydroxy-4-methylcoumarin have been synthesized and characterized by spectroscopic studies. Schiff-bases exhibit thiol–thione tautomerism wherein sulphur plays an important role in the coordination. The coordination possibility of the Schiff-bases towards metal ions have been proposed in the light of elemental analyses, spectral (IR, UV–vis, FAB-mass, ESR and fluorescence), magnetic and thermal studies. The low molar conductance values in DMF indicate that, the metal complexes are non-electrolytes. The cyclic voltammetric studies suggested that, the Cu(II) and Ni(II) complexes are of single electron transfer quasi-reversible nature. The Schiff-bases and its metal complexes have been evaluated for their in vitro antibacterial ( Escherichia coli , Staphilococcus aureus , Bascillus subtilis and Salmonella typhi ) and antifungal activities ( Candida albicans , Cladosporium and Aspergillus niger ) by MIC method. The Schiff-base I and its metal complexes exhibited DNA cleavage activity on isolated DNA of A. niger . |
| Databáze: | OpenAIRE |
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